Summary

Q96K31

Homolog: Q96EF9.
Function: Zinc fingers and homeoboxes protein 1, isoform 2.

Statistics

Total GO Annotation: 54
Unique PROST Go: 54
Unique BLAST Go: 0

Total Homologs: 34
Unique PROST Homologs: 30
Unique BLAST Homologs: 0

Structures and Sequence Alignment

The best structural homolog that predicted by 1. PB was Q96EF9 (Zinc fingers and homeoboxes protein 1, isoform 2) with a FATCAT P-Value: 2.58e-13 and RMSD of 2.62 angstrom. The sequence alignment identity is 73.1%.
Structural alignment shown in left. Query protein Q96K31 colored as red in alignment, homolog Q96EF9 colored as blue. Query protein Q96K31 is also shown in right top, homolog Q96EF9 showed in right bottom. They are colored based on secondary structures. 

  Q96K31 MDSGCWLFGGEFEDSVFEERPERRSGPPASYCAKLCEPQWFYEETESSDDVEVLTLKKFKGDLAYRRQEYQKALQEYSSISEKLSSTNFAMKRDVQEGQA 100
  Q96EF9 ------------------------------MLRKLW--QWFYEETESSDDVEVLTLKKFKGDLAYRRQEYQKALQEYSSISEKLSSTNFAMKRDVQEGQA 68

  Q96K31 RCLAHLGRHMEALEIAANLENKATNTDHLTTVLYLQLAICSSLQNLEKTIFCLQKLISLHPFNPWNWGKLAEAYLNLGPALSAALASSQKQHSFTSSDKT 200
  Q96EF9 RCLAHLGRHMEALEIAANLENKATNTDHLTTVLYLQLAICSSLQNLEKTIFCLQKLISLHPFNPWNWGKLAEAYLNLGPALSAALASSQKQHSFTSSDKT 168

  Q96K31 IKSFFPHSGKDCLLCFPETLPESSLFSVEANSSNSQKNEKALTNIQNCMAEKRETVLIETQLKACASFIRTRLLLQFTQPQQTSFALERNLRTQQEIEDK 300
  Q96EF9 IKSFFPHSGKDCLLCFPETLPESSLFSVEANSSNSQKNEKALTNIQNCMAEKRETVLIETQLKACASFIRTRLLLQFTQPQQTSFALERNLRTQQEIEDK 268

  Q96K31 MKGFSFKEDTLLLIAEV------MGEDIPEKIKDEVHPEVKCVGSVALTALVTVSSEEFEDKWFRKIKDHFCPFENQFHTEIQILA 380
  Q96EF9 MKGFSFKEDTLLLIAEVSVSLGFM-------------------------------------------------------------- 292

Go Annotations

1. PB indicates the go terms that are found by both PROST and BLAST.
2. P indicates the go terms that are found by only PROST.
3. B indicates the go terms that are only annotated by BLAST.
Source GO Description
2. P GO:0016239 positive regulation of macroautophagy
2. P GO:0030014 CCR4-NOT complex
2. P GO:0034388 Pwp2p-containing subcomplex of 90S preribosome
2. P GO:0045046 protein import into peroxisome membrane
2. P GO:0009556 microsporogenesis
2. P GO:0008277 regulation of G protein-coupled receptor signaling pathway
2. P GO:1905098 negative regulation of guanyl-nucleotide exchange factor activity
2. P GO:0010439 regulation of glucosinolate biosynthetic process
2. P GO:0006901 vesicle coating
2. P GO:0032040 small-subunit processome
2. P GO:0030154 cell differentiation
2. P GO:0030126 COPI vesicle coat
2. P GO:0010438 cellular response to sulfur starvation
2. P GO:0005769 early endosome
2. P GO:0006335 DNA replication-dependent chromatin assembly
2. P GO:0034511 U3 snoRNA binding
2. P GO:0034080 CENP-A containing chromatin assembly
2. P GO:0030544 Hsp70 protein binding
2. P GO:0051117 ATPase binding
2. P GO:0007399 nervous system development
2. P GO:0005732 sno(s)RNA-containing ribonucleoprotein complex
2. P GO:0008022 protein C-terminus binding
2. P GO:0007283 spermatogenesis
2. P GO:0005779 integral component of peroxisomal membrane
2. P GO:0009658 chloroplast organization
2. P GO:0005777 peroxisome
2. P GO:0005092 GDP-dissociation inhibitor activity
2. P GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
2. P GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway
2. P GO:0099518 vesicle cytoskeletal trafficking
2. P GO:0032991 protein-containing complex
2. P GO:0035457 cellular response to interferon-alpha
2. P GO:0044877 protein-containing complex binding
2. P GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
2. P GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
2. P GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
2. P GO:0034260 negative regulation of GTPase activity
2. P GO:0005634 nucleus
2. P GO:1990841 promoter-specific chromatin binding
2. P GO:0045087 innate immune response
2. P GO:0009615 response to virus
2. P GO:1901799 negative regulation of proteasomal protein catabolic process
2. P GO:0030686 90S preribosome
2. P GO:0016604 nuclear body
2. P GO:0000139 Golgi membrane
2. P GO:0030515 snoRNA binding
2. P GO:0001965 G-protein alpha-subunit binding
2. P GO:0007140 male meiotic nuclear division
2. P GO:0016558 protein import into peroxisome matrix
2. P GO:0051879 Hsp90 protein binding
2. P GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
2. P GO:0006891 intra-Golgi vesicle-mediated transport
2. P GO:0051607 defense response to virus
2. P GO:0005654 nucleoplasm

Homologs

1. PB indicates the homologs that are found by both PROST and BLAST.
2. P indicates homologs that are only found by PROST.
3. B indicates homologs that are only found by BLAST.

Source Homolog Description FATCAT p-val PROST Evalue BLAST Evalue
1. PB Q96K31 Uncharacterized protein C8orf76 0 3.71e-161 0.0
1. PB Q96EF9 Zinc fingers and homeoboxes protein 1, isoform 2 2.58e-13 1.97e-33 0.0
1. PB Q9D2X8 Uncharacterized protein C8orf76 homolog 7.75e-14 1.55e-50 8.55e-171
1. PB Q5BK24 Uncharacterized protein C8orf76 homolog 2.43e-10 2.86e-47 0.0
2. P M0RDU0 40-kDa huntingtin-associated protein 1.89e-04 1.01e-08 NA
2. P A5A6J9 Interferon-induced protein with tetratricopeptide repeats 3 1.74e-04 3.56e-02 NA
2. P Q8BGI5 Peroxisome assembly protein 26 7.72e-05 1.22e-03 NA
2. P Q5M990 Tetratricopeptide repeat protein 33 1.84e-05 5.99e-03 NA
2. P A1Z6M6 DNA polymerase interacting tetratricopeptide repeat-containing, protein of 47 kDa 3.00e-04 1.44e-02 NA
2. P Q6IR34 G-protein-signaling modulator 1 2.25e-03 3.89e-02 NA
2. P Q5EA11 Tetratricopeptide repeat protein 4 1.82e-04 4.82e-02 NA
2. P Q00558 40-kDa huntingtin-associated protein 1.28e-03 9.23e-08 NA
2. P P23610 40-kDa huntingtin-associated protein 1.18e-04 1.04e-06 NA
2. P Q8R3H9 Tetratricopeptide repeat protein 4 1.63e-04 1.21e-02 NA
2. P O13754 Hsp70/Hsp90 co-chaperone cns1 2.67e-04 1.06e-04 NA
2. P P33313 Hsp70/Hsp90 co-chaperone CNS1 2.85e-04 1.57e-04 NA
2. P Q54M20 Tetratricopeptide repeat protein 4 homolog 6.69e-04 3.19e-04 NA
2. P Q9FKV5 Protein POLLENLESS 3-LIKE 1 1.06e-04 7.75e-13 NA
2. P Q4R3V2 Spermatogenesis-associated protein 16 5.66e-04 2.36e-04 NA
2. P Q9D6K7 Tetratricopeptide repeat protein 33 7.95e-06 1.10e-02 NA
2. P P40509 Coatomer subunit epsilon 1.61e-04 3.53e-02 NA
2. P Q17886 Protein NASP homolog 1 1.58e-03 4.29e-02 NA
2. P Q6DE97 CCR4-NOT transcription complex subunit 10-A 3.32e-03 2.01e-02 NA
2. P A2A3L6 Tetratricopeptide repeat protein 24 1.01e-03 1.11e-02 NA
2. P Q95LZ5 Tetratricopeptide repeat protein 16 4.35e-03 4.55e-02 NA
2. P Q86YR5 G-protein-signaling modulator 1 1.36e-03 1.37e-02 NA
2. P Q8L730 Protein SULFUR DEFICIENCY-INDUCED 2 1.60e-03 6.57e-03 NA
2. P O60188 U3 small nucleolar RNA-associated protein 6 2.66e-04 1.84e-04 NA
2. P Q9SUC3 Protein POLLENLESS 3 1.37e-03 3.76e-07 NA
2. P Q9BE65 Peroxisome assembly protein 26 2.08e-04 1.04e-04 NA
2. P Q7Z412 Peroxisome assembly protein 26 5.71e-05 4.08e-05 NA
2. P Q9BXB7 Spermatogenesis-associated protein 16 2.13e-04 9.22e-03 NA
2. P Q9SD20 Protein POLLENLESS 3-LIKE 2 1.25e-03 1.09e-06 NA
2. P Q02354 U3 small nucleolar RNA-associated protein 6 3.54e-04 1.60e-03 NA