Results | PROST

Summary

Q9C0I3

Homolog: Q1RMS0.
Function: Serine-rich coiled-coil domain-containing protein 1.

Statistics

Total GO Annotation: 79
Unique PROST Go: 76
Unique BLAST Go: 0

Total Homologs: 29
Unique PROST Homologs: 24
Unique BLAST Homologs: 0

Structures and Sequence Alignment

The best structural homolog that predicted by 1. PB was Q1RMS0 (Serine-rich coiled-coil domain-containing protein 1) with a FATCAT P-Value: 0.000163 and RMSD of 11.81 angstrom. The sequence alignment identity is 72.4%.
Structural alignment shown in left. Query protein Q9C0I3 colored as red in alignment, homolog Q1RMS0 colored as blue. Query protein Q9C0I3 is also shown in right top, homolog Q1RMS0 showed in right bottom. They are colored based on secondary structures.

  Q9C0I3 MGDSGSRRSTLVSRLPIFRRSINRRHDSLPSSPSSSNTVGVHSSSPSSTNSSSGSTGKRRSIFRTPSISFHHKKGSEPKQEPTNQNLSISNGAQPGHSNM 100
  Q1RMS0 MGDSGSRRSTLVSRLPIFRRSISRKHDSLPSSPSSSNTVGVHSSSPSSTNSSSGSTGKRRSLFRTPSISFHHKKGSEPKQEPTNQNLSISNGAQPGQSSM 100

  Q9C0I3 QKLSLEEHIKTRGRHSVGFSSSRNKKITRSLTEDFEREKEHSTNKNVFINCLSSGKSEGDDSGFTEDQTRRSVKQSTRKLLPKSFSSHYKFSKPVLQSQS 200
  Q1RMS0 QKLSLEEHTKARGRHSVGFSSSRNKKITRSLTEDFEREKEHSTNKNVFINCLSSGKSEGDDSGFTEEQTRRSVKQSTKKLLTKSFSSHYKLSKPVPQSQS 200

  Q9C0I3 ISLVQQSEFSLEVTQYQEREPVLVRASPSCSVDVTERAGSSLQSPLLSADLTTAQTPSEFLALTEDSVSEMDAFSKSGSMASHCDNFGHNDSTSQMSLNS 300
  Q1RMS0 ISLVQQSEFSLEITQYQEREPVLVRGSPSCSVDVTERAGSSLQSPLLSADLTTAQTPSEFLALTEDSVSETDAFPKSGSMASHCDNLGHNDSTSQISPNP 300

  Q9C0I3 AAVTKTTTELTGTVPCAIMSPGKYRLEGQCSTESNSLPETSAANQKEVLLQIAELPATSVSHSESNLPA-DSEREENIGLQNGETMLGTNSPRKLGFYEQ 399
  Q1RMS0 AAVTKTTRDLRGTVPCAIVSPGKYRLEGRCSTESNSLPETSAAYQKEVLLQITKLPVMNGSDSETH-PSTDT-REDHIVIQNGETMLATSSPRKFGFYEH 398

  Q9C0I3 HKAIAEHVKGIHPISDSKIIPTSGDHHIFNKTSHGYEANPAKVLASSLSPFREGRFIERRLRSSSEGTAGSSRMILKPKDGNIEEVNSLRKQRAGSSSSK 499
  Q1RMS0 HKAIAERVKGIHPISDSRIIPSSGDHHVLNKTSYGYDANPAKVLASSLSPYREGRFIERRLRSSSEGTAGSSRMILKPKDGNVEEVNSLRKQRASSSSSK 498

  Q9C0I3 MNSLDVLNNLGSCELDEDDLMLDLEFLEEQSLHPSVCREDSYHSVVSCAAVVLTPMEPMIEMKKREEPEFPEPSKQNLSLKLTKDVDQEARCSHISRMPN 599
  Q1RMS0 MNSMDVLNNLGSCELDEDDLMLDLEFLEEQNLHPSVCREDSYHSVVSCAAVVLTPMEPTVEMKKREELKFREPSKQNLSLKLAKDIDQEARCSHIRGVPS 598

  Q9C0I3 SPSADWPLQGVEENGGIDSLPFRLMLQDCTAVKTLLLKMKRVLQESADMSPASSTTSLPVSPLTEEPVPFKDIMKDECSMLKLQLKEKDELISQLQEELG 699
  Q1RMS0 SPSSDWPLPSVEENGGIDSLPFRLMLQDCTAVKTLLLKMKRVLQESADMSPASSTTSLPVSPLAEEPLPFKDIMKDECSMLKLQLKEKDELISQLQEELE 698

  Q9C0I3 KVRHLQKAFASRVDKSTQTELLCYDGL-NLKRLET-VQGGREATYRNRIVSQNLSTRDRKAIHTPTEDRFRYSAADQTSPYKNKTCQLPSLCLSNFLKDK 797
  Q1RMS0 KVQHLQKAFASRVDKSTQTELLGYDALWN----PTCTEG----LFKP--V-HNIST-------------------------------------------- 743

  Q9C0I3 ELAEVIKHSRGTYETLTSDVTQNLRATVGQSSLKPTAKTEGLSTFLEKPKDQVATARQHSTFTGRFGQPPRGPISLHMYSRKNVFLHHNLHSTELQTLGQ 897
  Q1RMS0 ---------------------------------------------------------------------------------------------------- 743

  Q9C0I3 QDG 900
  Q1RMS0 --- 743

Go Annotations

1. PB indicates the go terms that are found by both PROST and BLAST.
2. P indicates the go terms that are found by only PROST.
3. B indicates the go terms that are only annotated by BLAST.

Source	GO	Description
1. PB	GO:0008017	microtubule binding
1. PB	GO:0001578	microtubule bundle formation
1. PB	GO:0015630	microtubule cytoskeleton
2. P	GO:0051010	microtubule plus-end binding
2. P	GO:0007015	actin filament organization
2. P	GO:0000082	G1/S transition of mitotic cell cycle
2. P	GO:0016055	Wnt signaling pathway
2. P	GO:0032886	regulation of microtubule-based process
2. P	GO:0019904	protein domain specific binding
2. P	GO:0070449	elongin complex
2. P	GO:0030374	nuclear receptor coactivator activity
2. P	GO:0007398	ectoderm development
2. P	GO:0046965	retinoid X receptor binding
2. P	GO:0043296	apical junction complex
2. P	GO:0005874	microtubule
2. P	GO:0002119	nematode larval development
2. P	GO:0008283	cell population proliferation
2. P	GO:0006368	transcription elongation from RNA polymerase II promoter
2. P	GO:0090734	site of DNA damage
2. P	GO:0030331	estrogen receptor binding
2. P	GO:0090090	negative regulation of canonical Wnt signaling pathway
2. P	GO:0030056	hemidesmosome
2. P	GO:0042974	retinoic acid receptor binding
2. P	GO:0030275	LRR domain binding
2. P	GO:0023052	signaling
2. P	GO:0030425	dendrite
2. P	GO:0030496	midbody
2. P	GO:0031489	myosin V binding
2. P	GO:0030476	ascospore wall assembly
2. P	GO:0000226	microtubule cytoskeleton organization
2. P	GO:0007052	mitotic spindle organization
2. P	GO:0022008	neurogenesis
2. P	GO:0008023	transcription elongation factor complex
2. P	GO:0019888	protein phosphatase regulator activity
2. P	GO:0042975	peroxisome proliferator activated receptor binding
2. P	GO:0000306	extrinsic component of vacuolar membrane
2. P	GO:0008157	protein phosphatase 1 binding
2. P	GO:0035259	glucocorticoid receptor binding
2. P	GO:0016922	nuclear receptor binding
2. P	GO:0001558	regulation of cell growth
2. P	GO:0022027	interkinetic nuclear migration
2. P	GO:0046966	thyroid hormone receptor binding
2. P	GO:0098978	glutamatergic synapse
2. P	GO:0031594	neuromuscular junction
2. P	GO:0007281	germ cell development
2. P	GO:0043473	pigmentation
2. P	GO:0051015	actin filament binding
2. P	GO:0005815	microtubule organizing center
2. P	GO:0005628	prospore membrane
2. P	GO:0030318	melanocyte differentiation
2. P	GO:0060090	molecular adaptor activity
2. P	GO:0016324	apical plasma membrane
2. P	GO:0030178	negative regulation of Wnt signaling pathway
2. P	GO:0098962	regulation of postsynaptic neurotransmitter receptor activity
2. P	GO:0016461	unconventional myosin complex
2. P	GO:0098981	cholinergic synapse
2. P	GO:0009950	dorsal/ventral axis specification
2. P	GO:0001725	stress fiber
2. P	GO:0043025	neuronal cell body
2. P	GO:0021987	cerebral cortex development
2. P	GO:0000902	cell morphogenesis
2. P	GO:0031929	TOR signaling
2. P	GO:0048578	positive regulation of long-day photoperiodism, flowering
2. P	GO:0051017	actin filament bundle assembly
2. P	GO:0031505	fungal-type cell wall organization
2. P	GO:0031931	TORC1 complex
2. P	GO:0045202	synapse
2. P	GO:0048576	positive regulation of short-day photoperiodism, flowering
2. P	GO:0017022	myosin binding
2. P	GO:0045159	myosin II binding
2. P	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding
2. P	GO:0030864	cortical actin cytoskeleton
2. P	GO:0043666	regulation of phosphoprotein phosphatase activity
2. P	GO:0000164	protein phosphatase type 1 complex
2. P	GO:0005912	adherens junction
2. P	GO:0060828	regulation of canonical Wnt signaling pathway
2. P	GO:0008013	beta-catenin binding
2. P	GO:0099572	postsynaptic specialization
2. P	GO:0032400	melanosome localization

Homologs

1. PB indicates the homologs that are found by both PROST and BLAST.
2. P indicates homologs that are only found by PROST.
3. B indicates homologs that are only found by BLAST.

Source	Homolog	Description	FATCAT p-val	PROST Evalue	BLAST Evalue
1. PB	Q3UHI0	Serine-rich coiled-coil domain-containing protein 2	1.79e-01	3.41e-08	2.09e-04
1. PB	Q9H7U1	Serine-rich coiled-coil domain-containing protein 2	2.20e-02	9.54e-10	1.48e-06
1. PB	Q1RMS0	Serine-rich coiled-coil domain-containing protein 1	1.63e-04	6.18e-17	0.0
1. PB	Q8C0C4	Serine-rich coiled-coil domain-containing protein 1	4.21e-04	4.16e-67	0.0
1. PB	Q9C0I3	Serine-rich coiled-coil domain-containing protein 1	0	2.64e-151	0.0
2. P	Q9Y608	Leucine-rich repeat flightless-interacting protein 2	3.37e-01	1.35e-03	NA
2. P	B1AZP2	Disks large-associated protein 4	1.98e-01	1.80e-03	NA
2. P	P97839	Disks large-associated protein 4	2.52e-01	2.45e-03	NA
2. P	Q6GNW0	Leucine-rich repeat flightless-interacting protein 2	2.73e-01	6.96e-04	NA
2. P	Q2M3G4	Protein Shroom1	1.58e-01	3.43e-03	NA
2. P	Q6GQV1	INSYN2B protein	9.97e-02	6.49e-06	NA
2. P	Q5SX79	Protein Shroom1	1.21e-01	4.52e-02	NA
2. P	G5EEK3	Non-centrosomal microtubule array protein 1	9.07e-02	3.24e-03	NA
2. P	Q9Y2H0	Disks large-associated protein 4	1.06e-01	2.11e-03	NA
2. P	Q03780	Uncharacterized protein YDR239C	4.29e-01	7.81e-03	NA
2. P	P38229	GLC7-interacting protein 1	5.20e-01	2.88e-02	NA
2. P	Q8IYF1	Elongin-A2	8.86e-02	3.66e-02	NA
2. P	Q9SNQ6	Protein HEADING DATE 3B	2.84e-01	3.13e-02	NA
2. P	F1RDM5	APC membrane recruitment protein 1	1.97e-01	4.48e-07	NA
2. P	E1C2Q8	APC membrane recruitment protein 2	1.05e-01	3.84e-02	NA
2. P	Q08921	Target of rapamycin complex 1 subunit TCO89	1.23e-01	4.75e-03	NA
2. P	Q6Y685	Transforming acidic coiled-coil-containing protein 1	1.96e-01	4.85e-03	NA
2. P	Q09560	Uncharacterized protein F36G3.1	9.36e-02	1.20e-02	NA
2. P	Q63187	Elongin-A	2.32e-01	1.20e-02	NA
2. P	O75410	Transforming acidic coiled-coil-containing protein 1	4.57e-02	2.22e-03	NA
2. P	Q75C80	Protein FYV8	1.16e-01	4.65e-02	NA
2. P	Q91V27	Melanophilin	7.20e-01	3.25e-02	NA
2. P	P33306	Protein BCK2	1.41e-01	2.38e-03	NA
2. P	O14273	Meiotically up-regulated protein C8C9.04	3.85e-01	2.68e-02	NA