Summary

Q9H6K5

Homolog: Q8N7X1.
Function: RNA-binding motif protein, X-linked-like-3.

Statistics

Total GO Annotation: 99
Unique PROST Go: 44
Unique BLAST Go: 54

Total Homologs: 39
Unique PROST Homologs: 31
Unique BLAST Homologs: 7

Structures and Sequence Alignment

The best structural homolog that predicted by 2. P was Q8N7X1 (RNA-binding motif protein, X-linked-like-3) with a FATCAT P-Value: 0.0118 and RMSD of 18.62 angstrom. The sequence alignment identity is 7.4%.
Structural alignment shown in left. Query protein Q9H6K5 colored as red in alignment, homolog Q8N7X1 colored as blue. Query protein Q9H6K5 is also shown in right top, homolog Q8N7X1 showed in right bottom. They are colored based on secondary structures. 

  Q9H6K5 MDNKRDKAKAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAGTSSRNPASRPPASGRG 100
  Q8N7X1 ---------------------------------------------------------------------------------------------------- 0

  Q9H6K5 ERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRP 200
  Q8N7X1 ---------------------------------------------------------------------------------------------------- 0

  Q9H6K5 PTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLS 300
  Q8N7X1 ---------------------------------------------------------------------------------------------------- 0

  Q9H6K5 SSPLATPSPSGTKARPVPPPDNAATPLPATLPPSPPVTPPPPAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQVPPT 400
  Q8N7X1 ---------------------------------------------------------------------------------------------------- 0

  Q9H6K5 QLIMSFPEAGVSSLATAAFVASVSPSVSSPLQSMPPTQANPALPSLPTLLSPLATPPLSAMSPLQGPVSPATSLGNSAFPLAALPQPGLSALTTPPPQAS 500
  Q8N7X1 ---------------------------------------------------------------------------------------------------- 0

  Q9H6K5 PSPSPPSLQATPHTLATLPLQDSPLLATLPLQASPSPLTTVSLQDPPLVSPSLLASPPLQAPPHPQAPPSMTTPPMQAPPSLQTIPPIQVPHSLTSPSLQ 600
  Q8N7X1 ---------------------------------------------------------------------------------------------------- 0

  Q9H6K5 APPSPLALSSLQATTSLGSPTLQATHSFLTMSPRQTQASLISPSRPASTPPDSPPLQAPLSLPASPPLQTSLSPAVSPLSSPLTIHPLQALSSLASHSPQ 700
  Q8N7X1 ---------------------------------------------------------------------------------------------------- 0

  Q9H6K5 APLSSLIMPPLETQSSLAPPSLQTPPASLTTPPLENLPSLAPPPLQTASAPLTTPPLENLPSLAPPPLQTASAPLTTPHLETPPCPAPCPLQAPPSPLTT 800
  Q8N7X1 ---------------------------------------------------------------------------------------------------- 0

  Q9H6K5 PPPETPSSIATPPPQAPPALASPPLQGLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPP-------LSPLATPSPQAPNALAV------HLLQAPF 887
  Q8N7X1 --------------------------------------------------------MMEADRPEKLFIGGLN-LKTD----EKALKAEFGKYGHIIKV-F 38

  Q9H6K5 ---SPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQVPPSPPA------SPPMSPSATPPPR 978
  Q8N7X1 LMKDRKTNKSRGFAFVTFESPADAKAAARDMNG-KYLDGKAIMVAQT--IKPAFKSS---------------RWVPPTPGSGSRSRFSHRTRGGGSSPQR 120

  Q9H6K5 VPPLLAAPPLQVPPSP-----------PASLPMSPLAK-PPPQ---APP-ALATPPLQALP-SPPASFPGQAPFSPSASLPMSPLATPPPQA-PP-VLAA 1059
  Q8N7X1 -------PPSQGRPDDGRGYAGYFDLWPYRAPM-PRKRGPPPRHWASPPHKRATP--SSLAHSVGCGMRGKAP-TVSGQDGYSGL-QPRRWAGPPHKRAV 208

  Q9H6K5 P---LLQVPPS--PPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGP---DLA----GHSSSATSTPE--ELRGYDSGPEGGAA 1145
  Q8N7X1 PRSSLARIGGSGMPGKAPAVW--------GQD-GYSGPRVR------EPLPPCRDPGDFV--PALRDYSRRYYGHS----SVPDYRPLRG-D-GNQNGYR 285

  Q9H6K5 ASPPPDAELAACHPAAWSRGP-APPLAFRGAP-G-APLPW--PPATGPGSADGLCTIY-ETEG--PES--------ATPA--PGAL--DPGPSPGTSGGK 1225
  Q8N7X1 GR---DHEYTD-HP---SKGSYREPLKSYGGPCGAAPV-WGTPPSYG-G---G-CR-YEEYQGNSPDACSEGRSSEALPVVLPDAYSRDHSPK-AYSGGR 370

  Q9H6K5 AAAGAGAGASSRSPKQARLGELPLGALQASVVQHLLSRTLLLAAAEGAAGGS-------G-----GGPG------G----AE-GG--------G-----V 1289
  Q8N7X1 SSSSNG---YSRSD---RYGE--EGC-----YEEYRGRS-----PDAHSGGRNSSSNSYGQSHHYGGEGRYEEYRGRSHEARSGGRSTDAHSRGRSDDAY 452

  Q9H6K5 TGGA-RAALSDA--ELGRWAELL-SPLDESRASITSVTSFSPDDVASPQG-D---WTVVEVETF----H------------------------------- 1346
  Q8N7X1 SGGHDSSSWSDCCGGGGRYEEYQGRSLDANSG------GCSPE--AYSGGHDNSSWS----DRYGVGGHYEENRGHSLDANSGGRSPDTHSGGHSSSSNS 540

  Q9H6K5 ---------------------------------------------------------------------------------------------------- 1346
  Q8N7X1 YGQSHRYGGEGRYEYRGRSHDAHSGGCSADAYSGGHDSSSQSNRYGGGGCYEEYRGRSLDANSGGRSPNAYSGGHDSSSWSHRYGGGGRYEEYRGRSLDA 640

  Q9H6K5 ---------------------------------------------------------------------------------------------------- 1346
  Q8N7X1 NSGGRSPDAYSGGHDSSGQSNCYGGGGRYEEYRGRLLDANSGGRSPDAYSGGHDSSSQSNRYGGGGRYEEYRGHSLDANSGGRSPDTYSRGHDSSSQSDH 740

  Q9H6K5 ---------------------------------------------------------------------------------------------------- 1346
  Q8N7X1 YGGGGRSLDANSSGRLPDAYSGGHDSSSRSHRYGGGGRYEEYRGRSLDANSGGRSPNAYSGGHNSSSRNDPCRGGGRYEENRGHSLDANSGGHSPNAYSG 840

  Q9H6K5 ---------------------------------------------------------------------------------------------------- 1346
  Q8N7X1 GRDSSSNSYDRSHRYGGGGHYEEYRGRSHDTHSRGRSPDAHSGDHYTEAYSRGRDSFSNSYGRSDHYGRGGCYEEYQGRSPNAYGGGRGLNSSNNSHGRS 940

  Q9H6K5 ---------------------------------------------------------------------------------------------------- 1346
  Q8N7X1 HRYGGGGRYEEYRGPSPDAHSGGRDSSIKSYGLSDRYGGGGHYEEYQGSLPDAYSGDHDRSSNSYGRSDRYSRGRDRVGRPDRGLPLPMETGSPPLHDSY 1040

  Q9H6K5 --------------------------- 1346
  Q8N7X1 SRSGCRVPRGGGRQGGRFERGEGRSRY 1067

Go Annotations

1. PB indicates the go terms that are found by both PROST and BLAST.
2. P indicates the go terms that are found by only PROST.
3. B indicates the go terms that are only annotated by BLAST.
Source GO Description
1. PB GO:0019901 protein kinase binding
2. P GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity
2. P GO:0018149 peptide cross-linking
2. P GO:0050901 leukocyte tethering or rolling
2. P GO:0010389 regulation of G2/M transition of mitotic cell cycle
2. P GO:0044853 plasma membrane raft
2. P GO:0005815 microtubule organizing center
2. P GO:0000307 cyclin-dependent protein kinase holoenzyme complex
2. P GO:0030216 keratinocyte differentiation
2. P GO:0030154 cell differentiation
2. P GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide
2. P GO:0017069 snRNA binding
2. P GO:0017025 TBP-class protein binding
2. P GO:0033234 negative regulation of protein sumoylation
2. P GO:0001618 virus receptor activity
2. P GO:0030036 actin cytoskeleton organization
2. P GO:0005796 Golgi lumen
2. P GO:0030097 hemopoiesis
2. P GO:0048599 oocyte development
2. P GO:0005689 U12-type spliceosomal complex
2. P GO:0030238 male sex determination
2. P GO:0031424 keratinization
2. P GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity
2. P GO:0044772 mitotic cell cycle phase transition
2. P GO:0051451 myoblast migration
2. P GO:0031490 chromatin DNA binding
2. P GO:0005854 nascent polypeptide-associated complex
2. P GO:0034237 protein kinase A regulatory subunit binding
2. P GO:0045667 regulation of osteoblast differentiation
2. P GO:0044099 polar tube
2. P GO:0051321 meiotic cell cycle
2. P GO:0006612 protein targeting to membrane
2. P GO:0009653 anatomical structure morphogenesis
2. P GO:0010224 response to UV-B
2. P GO:0016607 nuclear speck
2. P GO:0050902 leukocyte adhesive activation
2. P GO:0001931 uropod
2. P GO:0071933 Arp2/3 complex binding
2. P GO:1902465 negative regulation of histone H3-K27 trimethylation
2. P GO:0071354 cellular response to interleukin-6
2. P GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation
2. P GO:0050900 leukocyte migration
2. P GO:0007548 sex differentiation
2. P GO:0031941 filamentous actin
2. P GO:0001533 cornified envelope
3. B GO:0031433 telethonin binding
3. B GO:0051015 actin filament binding
3. B GO:0055013 cardiac muscle cell development
3. B GO:0010737 protein kinase A signaling
3. B GO:0044306 neuron projection terminus
3. B GO:0007527 adult somatic muscle development
3. B GO:0048769 sarcomerogenesis
3. B GO:0045859 regulation of protein kinase activity
3. B GO:0002020 protease binding
3. B GO:0031674 I band
3. B GO:0030136 clathrin-coated vesicle
3. B GO:0006941 striated muscle contraction
3. B GO:0050714 positive regulation of protein secretion
3. B GO:0060048 cardiac muscle contraction
3. B GO:0000794 condensed nuclear chromosome
3. B GO:0030315 T-tubule
3. B GO:0008307 structural constituent of muscle
3. B GO:0098793 presynapse
3. B GO:0055003 cardiac myofibril assembly
3. B GO:0036466 synaptic vesicle recycling via endosome
3. B GO:0030424 axon
3. B GO:0007076 mitotic chromosome condensation
3. B GO:0051371 muscle alpha-actinin binding
3. B GO:0005523 tropomyosin binding
3. B GO:0036309 protein localization to M-band
3. B GO:0031175 neuron projection development
3. B GO:0042383 sarcolemma
3. B GO:0030241 skeletal muscle myosin thick filament assembly
3. B GO:0005865 striated muscle thin filament
3. B GO:0043621 protein self-association
3. B GO:0043484 regulation of RNA splicing
3. B GO:0031430 M band
3. B GO:0006936 muscle contraction
3. B GO:0051592 response to calcium ion
3. B GO:0106311
3. B GO:0055008 cardiac muscle tissue morphogenesis
3. B GO:0106310 protein serine kinase activity
3. B GO:0017022 myosin binding
3. B GO:0031672 A band
3. B GO:0035995 detection of muscle stretch
3. B GO:0045214 sarcomere organization
3. B GO:0008021 synaptic vesicle
3. B GO:0150007 clathrin-dependent synaptic vesicle endocytosis
3. B GO:0048488 synaptic vesicle endocytosis
3. B GO:0044297 cell body
3. B GO:0050790 regulation of catalytic activity
3. B GO:0030240 skeletal muscle thin filament assembly
3. B GO:0016182 synaptic vesicle budding from endosome
3. B GO:0042805 actinin binding
3. B GO:0030018 Z disc
3. B GO:0003300 cardiac muscle hypertrophy
3. B GO:0004713 protein tyrosine kinase activity
3. B GO:0030122 AP-2 adaptor complex
3. B GO:0097493 structural molecule activity conferring elasticity

Homologs

1. PB indicates the homologs that are found by both PROST and BLAST.
2. P indicates homologs that are only found by PROST.
3. B indicates homologs that are only found by BLAST.

Source Homolog Description FATCAT p-val PROST Evalue BLAST Evalue
1. PB Q9H6K5 Proline-rich protein 36 0 7.16e-146 0.0
2. P Q5JRC9 Protein FAM47A 2.82e-01 2.54e-02 NA
2. P P24712 Involucrin 9.10e-01 3.09e-02 NA
2. P Q62563 Sex-determining region Y protein 7.98e-01 5.23e-03 NA
2. P Q8N3D4 EH domain-binding protein 1-like protein 1 1.60e-01 2.06e-03 NA
2. P P0DKJ7 Polycomb group protein FERTILIZATION-INDEPENDENT SEED 2 1.75e-01 4.13e-02 NA
2. P Q2KI51 Protein phosphatase 1 regulatory subunit 15A 4.20e-01 4.94e-02 NA
2. P Q5HY64 Putative protein FAM47C 9.80e-01 9.28e-03 NA
2. P Q5H9T9 Fibrous sheath CABYR-binding protein 4.34e-02 1.84e-02 NA
2. P B1B0V2 EZH inhibitory protein 3.38e-01 2.71e-07 NA
2. P O76942 Polar tube protein 1 6.85e-01 2.71e-02 NA
2. P P0C8Z4 RNA-binding motif protein, X-linked-like-3 NA 2.42e-03 NA
2. P Q8TAX7 Mucin-7 2.46e-01 1.09e-02 NA
2. P Q99MS7 EH domain-binding protein 1-like protein 1 8.60e-02 1.26e-02 NA
2. P Q5XPK0 Scar-like domain-containing protein WAVE 5 3.37e-02 6.65e-03 NA
2. P P70670 Nascent polypeptide-associated complex subunit alpha, muscle-specific form 1.50e-01 1.98e-02 NA
2. P P28550 Beta-casein 3.39e-01 7.38e-03 NA
2. P Q9XSE4 Beta-casein 8.51e-01 1.40e-03 NA
2. P P17941 Involucrin 8.82e-01 4.73e-02 NA
2. P Q28658 Small proline-rich protein 3 9.97e-01 1.35e-02 NA
2. P Q8WWL7 G2/mitotic-specific cyclin-B3 1.36e-02 8.28e-08 NA
2. P Q659K0 G2/mitotic-specific cyclin-B3 2.12e-02 8.93e-03 NA
2. P Q8N7X1 RNA-binding motif protein, X-linked-like-3 1.18e-02 1.15e-02 NA
2. P P0C2X8 Cell division cycle-associated protein 3 8.32e-01 2.80e-05 NA
2. P Q9ERZ0 Hemogen 1.56e-01 5.08e-04 NA
2. P Q196W1 Uncharacterized protein 099R NA 1.22e-02 NA
2. P P18175 Involucrin 9.39e-01 2.20e-02 NA
2. P Q8N402 Putative uncharacterized protein LOC388882 7.36e-01 4.61e-03 NA
2. P Q14242 P-selectin glycoprotein ligand 1 7.18e-01 1.15e-02 NA
2. P P0DKJ8 Polycomb group protein FERTILIZATION-INDEPENDENT SEED 2 3.00e-01 6.40e-03 NA
2. P Q9BXL5 Hemogen 1.56e-01 1.66e-04 NA
2. P Q08DY0 Glutamate-rich protein 5 6.13e-01 1.25e-03 NA
3. B Q8WZ42 Titin NA NA 0.006
3. B Q80TK0 AP2-interacting clathrin-endocytosis protein 3.88e-02 NA 4.86e-05
3. B D4A0X3 AP2-interacting clathrin-endocytosis protein 2.91e-02 NA 9.03e-06
3. B A8DYP0 Obscurin NA NA 0.001
3. B Q9UPP5 AP2-interacting clathrin-endocytosis protein 1.15e-01 NA 2.24e-06
3. B G4SLH0 Titin homolog NA NA 0.001
3. B Q8IVF2 Protein AHNAK2 NA NA 0.035