Summary
Structures and Sequence Alignment
The best structural homolog that predicted by 1. PB was
Q8R089
(Probable fibrosin-1) with a FATCAT P-Value: 3.18e-05 and RMSD of 8.07 angstrom. The sequence alignment identity is 93.8%.
Structural alignment shown in left. Query protein Q9HAH7 colored as red in alignment, homolog Q8R089 colored as blue.
Query protein Q9HAH7 is also shown in right top, homolog Q8R089 showed in right bottom. They are colored based on secondary structures.
Q9HAH7 MFEKYPGKMEGLFRHNPYTAFPPAVPGLPPGLPPAVSFGSLQGAFQPKSTNPELPPRLGPVPSGLSQKGTQIPDHFRPPLRKPGKWCAMHVRVAYMILRH 100 Q8R089 MFEKYPGKMEGLFRHNPYMAFPPAVPGLPPGLPPAVSFGSLQGAFQPKNTNPELPPRLGPVLSGLPQKGTQIPDHFRPPLRKPGKWCAMHVRVAYMILRH 100 Q9HAH7 QEKMKGDSHKLDFRNDLLPCLPGPYGALPPGQELSHPASLFTATGAVHAAANPFTAAPGAHGPFLSPSTHIDPFGRPTSFASLAALSNGAFGGLGSPTFN 200 Q8R089 QEKMKGDSHKLDFRNDLLPCLPGPYGALPPGQELSHPASLFTATGAVHAAANPFTTAPGAHGPFLSPSTHIDPFGRPTSFASLAALSNGAFGGLGSPTFN 200 Q9HAH7 SGAVFAQKESPGAPPAFASPPDPWGRLHRSPLTFPAWVRPPEAARTPGSDKERPVERREPSITKEEKDRDLPFSRPQLRVSPATPKARAGEEGPRPTKES 300 Q8R089 SSAVFAQKESPGAPPAFASPPDPWGRLHRSPLAFPAWVRPPETARTPGSDKERPMERREPSVTKEEKDRDLPFSRPQLRVSPATPKARAGEEGARPAKES 300 Q9HAH7 VRVKEERKEEAAAAAAAAAAAAAAAAAAA------TGPQGLHLLFERPRPPPFLGPSPPDRCAGFLEPTWLAAPPRLARPPRFYEAGEELTGPGAVAAAR 394 Q8R089 VRVKEERKEEAAAAAAAAAAAAAAAAAAAAAAAATTGPQGLHLLLERPRPPPFLGPSLPERCAGFPEPTWLAGPPRLARPPRFYEAGEELTGPGAMAAAR 400 Q9HAH7 LYGLEPAHPLLYSRLAPPPPPAAAPGTPHLLSKTPPGALLGAPPPLVPAPRPSSPPRGPGPARADR 460 Q8R089 LYSLDPAHPLLYSRLAPPPPPTATPGTPHLLSKTPPGALLGAPPPLVPAPRPSSPPRAPGPARADR 466
Go Annotations
1. PB indicates the go terms that are found by both PROST and BLAST.2. P indicates the go terms that are found by only PROST.
3. B indicates the go terms that are only annotated by BLAST.
| Source | GO | Description |
|---|---|---|
| 1. PB | GO:0008083 | growth factor activity |
| 1. PB | GO:0048146 | positive regulation of fibroblast proliferation |
| 2. P | GO:0005615 | extracellular space |
| 3. B | GO:0001764 | neuron migration |
| 3. B | GO:0003682 | chromatin binding |
| 3. B | GO:0030426 | growth cone |
| 3. B | GO:0035022 | positive regulation of Rac protein signal transduction |
| 3. B | GO:0031532 | actin cytoskeleton reorganization |
| 3. B | GO:0005856 | cytoskeleton |
| 3. B | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| 3. B | GO:0051571 | positive regulation of histone H3-K4 methylation |
| 3. B | GO:0097484 | dendrite extension |
| 3. B | GO:0010592 | positive regulation of lamellipodium assembly |
| 3. B | GO:0098582 | innate vocalization behavior |
| 3. B | GO:2000620 | positive regulation of histone H4-K16 acetylation |
| 3. B | GO:0048675 | axon extension |
| 3. B | GO:0060013 | righting reflex |
Homologs
1. PB indicates the homologs that are found by both PROST and BLAST.
2. P indicates homologs that are only found by PROST.
3. B indicates homologs that are only found by BLAST.
| Source | Homolog | Description | FATCAT p-val | PROST Evalue | BLAST Evalue |
|---|---|---|---|---|---|
| 1. PB | Q9HAH7 | Probable fibrosin-1 | 0 | 1.63e-141 | 0.0 |
| 1. PB | Q8R089 | Probable fibrosin-1 | 3.18e-05 | 5.76e-91 | 0.0 |
| 3. B | A0A087WPF7 | Autism susceptibility gene 2 protein homolog | 9.59e-01 | NA | 6.34e-59 |
| 3. B | Q8WXX7 | Autism susceptibility gene 2 protein | 6.53e-01 | NA | 6.85e-58 |
| 3. B | Q9HCM7 | Fibrosin-1-like protein | 7.07e-01 | NA | 3.35e-36 |