Summary
Structures and Sequence Alignment
The best structural homolog that predicted by 3. B was
Q8IZP1
(TBC1 domain family member 3) with a FATCAT P-Value: 0.0124 and RMSD of 2.76 angstrom. The sequence alignment identity is 12.6%.
Structural alignment shown in left. Query protein Q9UFV1 colored as red in alignment, homolog Q8IZP1 colored as blue.
Query protein Q9UFV1 is also shown in right top, homolog Q8IZP1 showed in right bottom. They are colored based on secondary structures.
Q9UFV1 ---------------------------------------------------------------------------------------------------- 0 Q8IZP1 MDVVEVAGSWWAQEREDIIMKYEKGHRAGLPEDKGPKPFRSYNNNVDHLGIVHETELPPLTAREAKQIRREISRKSKWVDMLGDWEKYKSSRKLIDRAYK 100 Q9UFV1 ---------------------------------------------------------------------------------------------------- 0 Q8IZP1 GMPMNIRGPMWSVLLNTEEMKLKNPGRYQIMKEKGKRSSEHIQRIDRDVSGTLRKHIFFRDRYGTKQRELLHILLAYEEYNPEVGYCRDLSHIAALFLLY 200 Q9UFV1 --------------------------------------------------MGHLDKEGLCTQGSSFSWLLRVLNDGISLGLTPCLWDMYLLEGEQMLMLI 50 Q8IZP1 LPEEDAFWALVQLLASERHSLQGFHSPNGGTVQGLQDQQEHVVATSQPKTMGHQDKKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQALMPI 300 Q9UFV1 TSIAFKV-QRSLYEETNKETWGP-A--TPRALKGTGRAR---PICESLHSSLQALTASESSRGPSLLQTPP----------R-VP---GQQALSRGDK-- 127 Q8IZP1 TRIAFKVQQKRL---TKTSRCGPWARFCNRFV-DT-WARDEDTVLKHLRASMKKLT---RKKG-DL--PPPAKPEQGSSASRPVPASRGGKTLCKGDRQA 389 Q9UFV1 --GISV-------SLSLPSLPSRRGRC-GRIIG------------------------------------------------------------------- 150 Q8IZP1 PPGPPARFPRPIWSASPPRAPRSSTPCPG---GAVREDTYPVGTQGVPSPALAQGGPQGSWRFLQWNSMPRLPTDLDVEGPWFRHYDFRQSCWVRAISQE 486 Q9UFV1 --------------------------------------------------------------- 150 Q8IZP1 DQLAPCWQAEHPAERVRSAFAAPSTDSDQGTPFRARDEQQCAPTSGPCLCGLHLESSQFPPGF 549
Go Annotations
1. PB indicates the go terms that are found by both PROST and BLAST.2. P indicates the go terms that are found by only PROST.
3. B indicates the go terms that are only annotated by BLAST.
| Source | GO | Description |
|---|---|---|
| 3. B | GO:0005886 | plasma membrane |
| 3. B | GO:0090630 | activation of GTPase activity |
| 3. B | GO:0005096 | GTPase activator activity |
| 3. B | GO:1903358 | regulation of Golgi organization |
| 3. B | GO:0007030 | Golgi organization |
| 3. B | GO:0031901 | early endosome membrane |
| 3. B | GO:0006886 | intracellular protein transport |
| 3. B | GO:0048227 | plasma membrane to endosome transport |
| 3. B | GO:0004843 | thiol-dependent deubiquitinase |
| 3. B | GO:0016579 | protein deubiquitination |
| 3. B | GO:0035526 | retrograde transport, plasma membrane to Golgi |
| 3. B | GO:0032588 | trans-Golgi network membrane |
| 3. B | GO:0006464 | cellular protein modification process |
| 3. B | GO:0055037 | recycling endosome |
| 3. B | GO:0060627 | regulation of vesicle-mediated transport |
| 3. B | GO:0019068 | virion assembly |
| 3. B | GO:0043547 | positive regulation of GTPase activity |
| 3. B | GO:0004197 | cysteine-type endopeptidase activity |
Homologs
1. PB indicates the homologs that are found by both PROST and BLAST.
2. P indicates homologs that are only found by PROST.
3. B indicates homologs that are only found by BLAST.
| Source | Homolog | Description | FATCAT p-val | PROST Evalue | BLAST Evalue |
|---|---|---|---|---|---|
| 1. PB | Q9UFV1 | Putative TBC1 domain family member 29 | 0 | 9.48e-157 | 9.79e-106 |
| 3. B | A0A087WVF3 | TBC1 domain family member 3D | 2.12e-02 | NA | 5.23e-17 |
| 3. B | A0A087X1G2 | TBC1 domain family member 3K | 1.59e-02 | NA | 5.13e-17 |
| 3. B | P0C7X1 | TBC1 domain family member 3H | 3.01e-02 | NA | 5.38e-17 |
| 3. B | A6NDS4 | TBC1 domain family member 3B | 2.55e-02 | NA | 1.79e-17 |
| 3. B | A0A087X179 | TBC1 domain family member 3E | 5.12e-02 | NA | 5.59e-17 |
| 3. B | Q6DHY5 | TBC1 domain family member 3G | 1.45e-02 | NA | 5.08e-17 |
| 3. B | Q6IPX1 | TBC1 domain family member 3C | 2.70e-02 | NA | 5.49e-17 |
| 3. B | Q8IZP1 | TBC1 domain family member 3 | 1.24e-02 | NA | 5.49e-17 |
| 3. B | A0A087WXS9 | TBC1 domain family member 3I | 3.28e-02 | NA | 5.59e-17 |
| 3. B | P35125 | Ubiquitin carboxyl-terminal hydrolase 6 | 7.28e-01 | NA | 3.03e-16 |
| 3. B | Q92738 | USP6 N-terminal-like protein | 4.91e-01 | NA | 0.002 |
| 3. B | A6NER0 | TBC1 domain family member 3F | 4.18e-02 | NA | 5.23e-17 |
| 3. B | B9A6J9 | TBC1 domain family member 3L | 2.35e-02 | NA | 5.23e-17 |